Why Platelet Rich Fibrin?

Platelet Rich Plasma and Fibrin

Platelet-rich plasma (PRP) releases all platelets and growth factor immediately (Immediate Release); however, platelet-rich-fibrin matrix (PRFM) reserves and hold platelets and growth factors in fibrin matrix and releases platelets and growth factors over 7-10 days (Extended Released).

Both PRP and PRFM can be used for various skin rejuvenation purposes. 

PRP is commonly employed for facial rejuvenation, addressing concerns such as fine lines, wrinkles, and volume loss. It is also effective in improving the appearance of scars and promoting hair regrowth. 

PRFM, with its enhanced longevity and sustained effects, is particularly beneficial for managing hair treatments  or treating larger areas and more complex skin conditions, such as deep wrinkles, acne scars, and stretch marks.

Here are more details about PRFM vs PRP:

1. Composition and Preparation:
The first distinction lies in their composition and preparation. PRP is obtained by drawing a small amount of the patient's blood and processing it in a centrifuge to separate the platelet-rich plasma from other components. PRFM, on the other hand, involves an additional step. After obtaining PRP, you need to add an activator. The PRP undergoes further processing to create a fibrin matrix. This matrix enhances the stability and longevity of platelets and growth factors, maximizing their regenerative potential. Clinical studies are showing PRFM obtains higher concentration and more varieties of growth factors.

2. Concentration and Release:
PRP contains a higher concentration of platelets compared to the baseline of the whole blood of the same patient. with platelet concentrations ranging from 2 to 3 folds higher (over 1,000,000 platelets per ml). PRFM takes it a step further by achieving even higher platelet concentrations. Additionally, PRFM's fibrin matrix acts as a reservoir, enabling the extended release of growth factors and platelets over an extended period (7-10 days). This sustained release enhances the skin or hair 's rejuvenation process and provides longer-lasting results.

3. Gel-like Texture:

While PRP has a liquid consistency, PRFM has a unique gel-like texture due to the fibrin matrix. This gel-like nature allows for precise application and better interaction between platelets and surrounding tissues. The texture of PRFM facilitates targeted delivery, ensuring optimal contact with the treatment area for maximum rejuvenation effects.

4. Longevity of Results:
One of the significant advantages of PRFM over PRP is the longevity of results. While PRP provides short-term rejuvenation benefits lasting a few weeks to a few months, PRFM offers longer-lasting effects. The fibrin matrix in PRFM acts as a scaffold, gradually releasing growth factors and promoting prolonged tissue regeneration. This sustained release leads to more durable improvements in skin texture, tone, and overall rejuvenation.

5. Indicated Use and Treatment Areas:
Both PRP and PRFM can be used for various skin rejuvenation purposes. PRP is commonly employed for facial rejuvenation, addressing concerns such as fine lines, wrinkles, and volume loss. It is also effective in improving the appearance of scars and promoting hair regrowth. PRFM, with its enhanced longevity and sustained effects, is particularly beneficial for treating larger areas and more complex skin conditions, such as deep wrinkles, acne scars, and stretch marks.

Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin Matrix (PRFM) offer exciting advancements in skin rejuvenation treatments. PRP utilizes platelet-rich plasma, while PRFM takes it a step further by incorporating a fibrin matrix. Understanding the key differences between these two therapies is essential when selecting the most suitable option for your specific skin concerns and desired outcomes. Whether you prefer the versatility of PRP or the longer-lasting effects of PRFM.